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| 从TNT的结果看：LDL应该降低到什么水平？
TNT（Treating to New Targets）研究结果最近在ACC2005年会上报告。它反映降LDL越积极，病人的预后越好。对大多数医生来说，不感意外。以前已有多项研究提示这一认识。例如PROVE-IT反映80mg Atorvastatin用于ACS病人，优于40mg Pravastatin；REVERSAL比较此两种药物，反映Atorvastatin遏制动脉粥样硬化进程更有效（Cannon CP. Braunwald E etal. Intensive versus Moderate lowering Lipid-Lowering with statin after ACS. NEJM 2004; 350: 1495; Nissan SE etal. Effect of intensive versus moderate lipid-lowering therapy on progression of coronary atheroscherosis, randomized controlled trial JAMA 2004; 291: 1071）。此外，HPS和ASCOT-LLA表明，无论病人基础胆固醇水平高、低，均获益于他汀治疗（MRC/BHF Heart Protection Study of Cholesterol lowering with simvastatin in 25,536 high risk individual. a randomized placebo controlled trial .Lancet 2002; 360: 7; Socer PS etal. Prevention of coronary and cardiova
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